OTC medicine

Dolo 650 Tablet

Paracetamol (650mg)

A paracetamol brand used for the temporary relief of fever and mild to moderate pain.

Manufacturer: Micro Labs Ltd
Pack: strip of 15 tablets
Dosage form: tablet
Indicative MRP: ₹33.90

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Dolo 650 Tablet contains Paracetamol (acetaminophen), one of the most widely used medicines for reducing fever and relieving mild to moderate pain. It is generally well tolerated when taken at the recommended dose and is gentler on the stomach than most other common pain relievers.

Uses of Dolo 650 Tablet

Fever
Headache and migraine
Body ache and muscle pain
Toothache and dental pain
Aches associated with cold and flu
Period (menstrual) pain

Benefits of Dolo 650 Tablet

Pain relief: Dolo 650 Tablet blocks the chemical messengers in the brain that signal pain, easing headaches, body aches and other everyday pain without irritating the stomach lining the way NSAIDs can.

Fever reduction: It acts on the heat-regulating centre in the brain (hypothalamus) to bring a raised body temperature back toward normal, usually within 30 to 60 minutes of a dose.

Side effects of Dolo 650 Tablet

Most people experience no side effects at the recommended dose. Uncommon effects include nausea and skin rash.

Seek medical help immediately for signs of an allergic reaction (swelling of the face or throat, difficulty breathing) or a severe skin reaction (blistering, peeling).
Taking more than the recommended amount can cause serious liver damage, even before any symptoms appear.

How to use Dolo 650 Tablet

Swallow the tablet whole with a glass of water; do not chew or crush it.
It can be taken with or without food, but taking it after food reduces the chance of stomach upset.
Leave a gap of at least 4 to 6 hours between doses.
Do not take more than 4 doses (a maximum of 4 g of Paracetamol in total) in 24 hours.

How Dolo 650 Tablet works

Dolo 650 Tablet works mainly in the brain and spinal cord. It reduces the production of prostaglandins — chemical messengers that cause pain and raise body temperature — by inhibiting cyclo-oxygenase (COX) enzymes centrally. This relieves pain and resets the body temperature set-point during fever.

What if you miss or exceed a dose?

If you miss a dose

Dolo 650 Tablet is usually taken only when needed. If you are on a schedule and miss a dose, take it as soon as you remember — unless it is almost time for the next dose. Never take a double dose to make up for a missed one.

In case of overdose

An overdose of Dolo 650 Tablet can cause serious, sometimes fatal, liver damage. Symptoms may not appear for 24 hours or more, so seek emergency medical care immediately after a suspected overdose even if you feel well.

Substitutes

Calpol 650 TabletGlaxoSmithKline Pharmaceuticals Ltd₹30.50

Same composition as Dolo 650 Tablet. Prices are indicative MRP. Never switch medicines on your own — confirm any substitute with your doctor or pharmacist.

See all substitutes →

Safety advice

AlcoholUnsafe

Avoid alcohol; the combination increases the risk of liver damage.

PregnancyConsult your doctor

Generally considered the preferred pain reliever in pregnancy, but use only at the lowest effective dose after consulting a doctor.

BreastfeedingSafe

Considered safe during breastfeeding; only small amounts pass into breast milk.

DrivingSafe

Does not usually affect the ability to drive or use machines.

KidneyUse with caution

Use with caution in significant kidney disease; a longer gap between doses may be needed.

LiverUse with caution

Use with caution in liver disease and avoid in severe liver impairment; ask a doctor first.

Quick tips

Many cold, flu and combination pain medicines already contain Paracetamol — check labels so you do not double up.
Avoid alcohol while taking Dolo 650 Tablet; the combination increases the risk of liver damage.
See a doctor if fever lasts more than 3 days or pain lasts more than 5 days despite treatment.
For children, use a paediatric preparation dosed by body weight, not adult tablets.

Interactions with other medicines

Warfarin and other blood thinners: regular daily use of Dolo 650 Tablet may increase bleeding risk; occasional doses are usually acceptable — ask your doctor.
Carbamazepine, phenytoin, rifampicin: these increase the risk of liver injury from Dolo 650 Tablet.
Cholestyramine: reduces Dolo 650 Tablet absorption; separate the doses by at least 1 hour.
Alcohol: increases the risk of liver damage.

Fact box

Chemical class: Para-aminophenol derivative
Habit forming: No
Therapeutic class: Analgesic and antipyretic
Action class: Central COX inhibitor
Storage: Store below 25°C in a dry place, protected from light. Keep out of reach of children.

Frequently asked questions

How quickly does Dolo 650 Tablet work?

It usually starts relieving pain and fever within 30 to 60 minutes, and the effect lasts about 4 to 6 hours.

Can I take Dolo 650 Tablet with ibuprofen?

They can be combined for short periods in adults if a doctor advises it, since they work in different ways — but do not combine them on your own for children.

What is the maximum safe dose in a day?

Adults should not exceed 4 g of Paracetamol in 24 hours from all sources, including combination cold and flu remedies.

Is Dolo 650 Tablet safe for long-term daily use?

It is intended for short-term relief. If you need it daily for more than a few days, see a doctor to find and treat the underlying cause.

Is Dolo 650 Tablet an antibiotic?

No. It only relieves pain and fever; it does not treat the infection causing them.

Active ingredients

Analgesic / Antipyretic

Paracetamol 650mg Tablet

Active ingredientParacetamolStrength650mgFormtablet

Dolo 650 Tablet contains Paracetamol (acetaminophen), one of the most widely used medicines for reducing fever and relieving mild to moderate pain. It is generally well tolerated when taken at the…

Last reviewed: 2026-07-28
Reference: Open reference ↗

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